Andrew B. Chung, MD/PhD
2014-10-08 03:20:17 UTC
Diabet Med. 2012 Oct 17. doi: 10.1111/dme.12039.
The 2012 Banting Lecture Reversing the twin cycles of Type 2 diabetes.
It has become widely accepted that type 2 diabetes is inevitably life-long,
with irreversible and progressive beta cell damage. However, the restoration
of normal glucose metabolism within days after bariatric surgery in the
majority of people with type 2 diabetes disproves this concept. There is now
no doubt that this reversal of diabetes depends upon the sudden and profound
decrease in food intake, and does not relate to any direct surgical effect.
The Counterpoint study demonstrated that normal glucose levels and normal
beta cell function could be restored by a very low calorie diet alone. Novel
magnetic resonance methods were applied to measure intra-organ fat. The
results showed two different time courses: a) resolution of hepatic insulin
sensitivity within days along with a rapid fall in liver fat and
normalisation of fasting glucose levels; and b) return of normal beta cell
insulin secretion over weeks in step with a fall in pancreas fat. Now that
it has been possible to observe the pathophysiological events during
reversal of type 2 diabetes, the reverse time course of events which
determine the onset of the condition can be identified. The twin cycle
hypothesis postulates that chronic calorie excess leads to accumulation of
liver fat with eventual spill over into the pancreas. These self-reinforcing
cycles between liver and pancreas eventually cause metabolic inhibition of
insulin secretion after meals and onset of hyperglycaemia. It is now clear
that Type 2 diabetes is a reversible condition of intra-organ fat excess to
which some people are more susceptible than others.
PMID: 23075228
Yes, stopping the causative overeating without harmfulThe 2012 Banting Lecture Reversing the twin cycles of Type 2 diabetes.
It has become widely accepted that type 2 diabetes is inevitably life-long,
with irreversible and progressive beta cell damage. However, the restoration
of normal glucose metabolism within days after bariatric surgery in the
majority of people with type 2 diabetes disproves this concept. There is now
no doubt that this reversal of diabetes depends upon the sudden and profound
decrease in food intake, and does not relate to any direct surgical effect.
The Counterpoint study demonstrated that normal glucose levels and normal
beta cell function could be restored by a very low calorie diet alone. Novel
magnetic resonance methods were applied to measure intra-organ fat. The
results showed two different time courses: a) resolution of hepatic insulin
sensitivity within days along with a rapid fall in liver fat and
normalisation of fasting glucose levels; and b) return of normal beta cell
insulin secretion over weeks in step with a fall in pancreas fat. Now that
it has been possible to observe the pathophysiological events during
reversal of type 2 diabetes, the reverse time course of events which
determine the onset of the condition can be identified. The twin cycle
hypothesis postulates that chronic calorie excess leads to accumulation of
liver fat with eventual spill over into the pancreas. These self-reinforcing
cycles between liver and pancreas eventually cause metabolic inhibition of
insulin secretion after meals and onset of hyperglycaemia. It is now clear
that Type 2 diabetes is a reversible condition of intra-organ fat excess to
which some people are more susceptible than others.
PMID: 23075228
undernourishment by holding to the right amount, which is 32 oz of
daily food, is the absolutely only **healthy** way to remove the
"intra-organ fat excess" ( http://WDJW.net/VAT ) that happens with
overeating:
https://groups.google.com/group/sci.med.cardiology/msg/48e684b2a336961e?
Yes, right amount ( http://WDJW.net/2PD-OMER Approach ) control as
Chris Malcolm, MU, **and** Rod Eastman are doing is much more
sophisticated and smarter:
http://groups.google.com/group/alt.support.diet.low-carb/msg/8d2ef74488074acf?
and
http://groups.google.com/group/sci.med.cardiology/msg/522ce5c058224656?
**and**
http://groups.google.com/group/sci.med.cardiology/msg/da03131060efa3b5?
http://groups.google.com/group/sci.med.cardiology/msg/055f2e7cf3c590ee?
So don't be an Ayoob or you will most certainly die a horrible (Mark
9:42) death:
https://groups.google.com/group/sci.med.cardiology/msg/9c87c24ea7a7ee20?
Be hungrier, which really is wonderfully healthier especially for
diabetics and other heart disease patients:
http://bit.ly/HeartDoc777-touts-hunger (Luke 6:21a) with all glory to
GOD, Who causes us to hunger (Deuteronomy 8:3) when He blesses us
right now (Luke 6:21a) thereby removing the http://WDJW.net/VAT
... because we mindfully choose to openly care with our heart,
Andrew <><
--
Andrew B. Chung, MD/PhD
Emory's IMVC.org cardiologist (GA Lic#040347)
and author of the 2PD-OMER Approach:
http://WDJW.net/Luke2442
which is the only **healthy** way to cure T2DM