Can a good diet prevent dementia?

[⊙＿⊙]

Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016

Question

Can a good diet prevent dementia?


Response from David B. Reuben, MD

Professor and Archstone Foundation Endowed Chair, Department of Medicine, University of California, Los Angeles; Chief, Division of Geriatrics, UCLA Medical Center, Santa Monica, California


Dietary interventions to prevent dementia or cognitive decline are generally safe, readily available, and can be easier to implement than interventions such as exercise. But evidence supporting these interventions varies. Perhaps the best studied is the Mediterranean diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds, legumes, fish, and olive oil, and low in red meat, poultry, dairy, and alcohol. The dietary approach to stop hypertension (DASH) diet is similar, but is higher in low-fat dairy and lower in fish. The Mediterranean–DASH intervention for neurodegenerative delay (MIND) diet incorporates elements of both these diets but places more emphasis on berries, nuts, and beans.

A meta-analysis of prospective cohort studies showed that people who adhere to a Mediterranean diet have lower rates of Alzheimer disease and Parkinson disease.[1] Similarly, studies of community-dwelling older people who followed the MIND diet showed less decline in global episodic, semantic, and working memory and in perceptual speed and perceptual organization at 4.7-year follow-up.[2] In addition, these study participants were less likely to have developed Alzheimer disease at 4.5-year follow-up.[3]

Data from some randomized clinical trials support the use of these diets to prevent cognitive decline and dementia. In the PREDIMED study, participants 55-80 years of age at high risk for cardiovascular disease were randomly assigned to one of three diets: a Mediterranean diet with supplemental extra-virgin olive oil, a Mediterranean diet with supplemental mixed nuts, or a regular diet that emphasized reduced dietary fat. There was a reduction in the composite of myocardial infarction, stroke, and death from cardiovascular causes—the primary endpoint—with the supplemented Mediterranean diets.[4] A secondary analysis demonstrated higher scores on the Mini-Mental State Examination and the clock-drawing test at 6.5 years.[5] In a short-term study, participants randomized to a DASH diet had better psychomotor speed at 4-month follow-up.[6]


This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia.

Diet can also be effective when it is part of a multicomponent intervention. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER),[7] 1260 participants with cardiovascular risk factors for dementia and cognitive performance at the mean or slightly lower than expected for age were randomly assigned to a multicomponent intervention (diet, exercise, cognitive training, and vascular risk monitoring) or to health advice (control group).The dietary component included fruit and vegetables, whole-grain cereal products, low-fat milk and meat products, low sugar, margarine instead of butter, and at least two portions of fish per week. The primary outcome measure was change in performance on a neuropsychological test battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB composite score was 25% higher in the intervention group than in the control group, and executive functioning and processing speed were better in the intervention group. However, memory was no better in the intervention group than in the control group.

This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia. Coupled with other benefits related to hypertension and cardiovascular disease,[4,8] clinicians should consider recommending these diets for appropriate older people.

Developed in association with the UCLA Alzheimer's and Dementia Care Program.

References

Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.

Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract

Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015;11:1007-1014. Abstract

Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-1290. Abstract

Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84:1318-1325. Abstract

Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 2010;55:1331-1338. Abstract

Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255-2263. Abstract

Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the Dietary Approach to stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015;113:1-15. Abstract


Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.

http://www.medscape.com/viewarticle/869379

[A little knowledge]

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?
Response from David B. Reuben, MD
Professor and Archstone Foundation Endowed Chair, Department of Medicine, University of California, Los Angeles; Chief, Division of Geriatrics, UCLA Medical Center, Santa Monica, California
Dietary interventions to prevent dementia or cognitive decline are generally safe, readily available, and can be easier to implement than interventions such as exercise. But evidence supporting these interventions varies. Perhaps the best studied is the Mediterranean diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds, legumes, fish, and olive oil, and low in red meat, poultry, dairy, and alcohol. The dietary approach to stop hypertension (DASH) diet is similar, but is higher in low-fat dairy and lower in fish. The Mediterranean–DASH intervention for neurodegenerative delay (MIND) diet incorporates elements of both these diets but places more emphasis on berries, nuts, and beans.
A meta-analysis of prospective cohort studies showed that people who adhere to a Mediterranean diet have lower rates of Alzheimer disease and Parkinson disease.[1] Similarly, studies of community-dwelling older people who followed the MIND diet showed less decline in global episodic, semantic, and working memory and in perceptual speed and perceptual organization at 4.7-year follow-up.[2] In addition, these study participants were less likely to have developed Alzheimer disease at 4.5-year follow-up.[3]
Data from some randomized clinical trials support the use of these diets to prevent cognitive decline and dementia. In the PREDIMED study, participants 55-80 years of age at high risk for cardiovascular disease were randomly assigned to one of three diets: a Mediterranean diet with supplemental extra-virgin olive oil, a Mediterranean diet with supplemental mixed nuts, or a regular diet that emphasized reduced dietary fat. There was a reduction in the composite of myocardial infarction, stroke, and death from cardiovascular causes—the primary endpoint—with the supplemented Mediterranean diets.[4] A secondary analysis demonstrated higher scores on the Mini-Mental State Examination and the clock-drawing test at 6.5 years.[5] In a short-term study, participants randomized to a DASH diet had better psychomotor speed at 4-month follow-up.[6]
This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia.
Diet can also be effective when it is part of a multicomponent intervention. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER),[7] 1260 participants with cardiovascular risk factors for dementia and cognitive performance at the mean or slightly lower than expected for age were randomly assigned to a multicomponent intervention (diet, exercise, cognitive training, and vascular risk monitoring) or to health advice (control group).The dietary component included fruit and vegetables, whole-grain cereal products, low-fat milk and meat products, low sugar, margarine instead of butter, and at least two portions of fish per week. The primary outcome measure was change in performance on a neuropsychological test battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB composite score was 25% higher in the intervention group than in the control group, and executive functioning and processing speed were better in the

intervention

Post by ⊙＿⊙
group. However, memory was no better in the intervention group than in the control group.
This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia. Coupled with other benefits related to hypertension and cardiovascular disease,[4,8] clinicians should consider recommending these diets for appropriate older people.
Developed in association with the UCLA Alzheimer's and Dementia Care Program.
References
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract
Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015;11:1007-1014. Abstract
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-1290. Abstract
Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84:1318-1325. Abstract
Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 2010;55:1331-1338. Abstract
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255-2263. Abstract
Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the Dietary Approach to stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015;113:1-15. Abstract
Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.
http://www.medscape.com/viewarticle/869379
---
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http://www.alzheimersanddementia.com/article/S1552-5260(13)01294-6/fulltext

"A molecular mechanism by which acidosis of the brain can lead to
Alzheimer's disease

Conclusions

These findings suggest the involvement of brain acidosis in the
etiopathogenesis of AD, and AEP-I 2 PP2A -PP2A-tau
hyperphosphorylation pathway as a therapeutic target."

--
A little knowledge is a dangerous thing


"The U.S. government does not study anything holistically. Everything
is studied in isolation from all else."
-- The Open-Source Everything Manifesto: Transparency, Truth, and
Trust (Manifesto Series) by Robert David Steele
http://www.phibetaiota.net/2014/05/robert-steele-at-libtechnyc-the-open-source-everything-manifesto/

http://www.collective-evolution.com/2013/01/07/the-origin-of-education-and-mandatory-schooling/
"From an early age, we are forced into a mandatory school system that
requires and encourages youth to attend for a large portion of their
human life, for six hours a day. Each child is required to learn the
accepted version of reality in order to fit into the specific mold
desired by the elite. Just like television, a large part of school is
simply programming. It’s ironic how the same families behind the
funding are responsible for many inhumane atrocities that took place
throughout history. They are also behind big oil, big pharma, food and
other industries that are becoming more transparent as of late. Kids
who do not fit into the system and do not resonate with it are usually
labelled and medicated. Essentially, the whole point of school is to
shape the reality of the student."

[Bob Officer]

Post by ⊙＿⊙

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?
Response from David B. Reuben, MD
Professor and Archstone Foundation Endowed Chair, Department of
Medicine, University of California, Los Angeles; Chief, Division of
Geriatrics, UCLA Medical Center, Santa Monica, California
Dietary interventions to prevent dementia or cognitive decline are
generally safe, readily available, and can be easier to implement than
interventions such as exercise. But evidence supporting these
interventions varies. Perhaps the best studied is the Mediterranean
diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds,
legumes, fish, and olive oil, and low in red meat, poultry, dairy, and
alcohol. The dietary approach to stop hypertension (DASH) diet is
similar, but is higher in low-fat dairy and lower in fish. The
Mediterranean–DASH intervention for neurodegenerative delay (MIND) diet
incorporates elements of both these diets but places more emphasis on
berries, nuts, and beans.
A meta-analysis of prospective cohort studies showed that people who
adhere to a Mediterranean diet have lower rates of Alzheimer disease and
Parkinson disease.[1] Similarly, studies of community-dwelling older
people who followed the MIND diet showed less decline in global
episodic, semantic, and working memory and in perceptual speed and
perceptual organization at 4.7-year follow-up.[2] In addition, these
study participants were less likely to have developed Alzheimer disease
at 4.5-year follow-up.[3]
Data from some randomized clinical trials support the use of these diets
to prevent cognitive decline and dementia. In the PREDIMED study,
participants 55-80 years of age at high risk for cardiovascular disease
were randomly assigned to one of three diets: a Mediterranean diet with
supplemental extra-virgin olive oil, a Mediterranean diet with
supplemental mixed nuts, or a regular diet that emphasized reduced
dietary fat. There was a reduction in the composite of myocardial
infarction, stroke, and death from cardiovascular causes—the primary
endpoint—with the supplemented Mediterranean diets.[4] A secondary
analysis demonstrated higher scores on the Mini-Mental State Examination
and the clock-drawing test at 6.5 years.[5] In a short-term study,
participants randomized to a DASH diet had better psychomotor speed at
4-month follow-up.[6]
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia.
Diet can also be effective when it is part of a multicomponent
intervention. In the Finnish Geriatric Intervention Study to Prevent
Cognitive Impairment and Disability (FINGER),[7] 1260 participants with
cardiovascular risk factors for dementia and cognitive performance at
the mean or slightly lower than expected for age were randomly assigned
to a multicomponent intervention (diet, exercise, cognitive training,
and vascular risk monitoring) or to health advice (control group).The
dietary component included fruit and vegetables, whole-grain cereal
products, low-fat milk and meat products, low sugar, margarine instead
of butter, and at least two portions of fish per week. The primary
outcome measure was change in performance on a neuropsychological test
battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB
composite score was 25% higher in the intervention group than in the
control group, and executive functioning and processing speed were better in the

intervention

Post by ⊙＿⊙
group. However, memory was no better in the intervention group than in the control group.
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia. Coupled with other
benefits related to hypertension and cardiovascular disease,[4,8]
clinicians should consider recommending these diets for appropriate older people.
Developed in association with the UCLA Alzheimer's and Dementia Care Program.
References
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to
Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline
with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract
Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND
diet associated with reduced incidence of Alzheimer's disease.
Alzheimers Dement. 2015;11:1007-1014. Abstract
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of
cardiovascular disease with a Mediterranean diet. N Engl J Med.
2013;368:1279-1290. Abstract
Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet
improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol
Neurosurg Psychiatry. 2013;84:1318-1325. Abstract
Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary
approaches to stop hypertension diet, exercise, and caloric restriction
on neurocognition in overweight adults with high blood pressure.
Hypertension. 2010;55:1331-1338. Abstract
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain
intervention of diet, exercise, cognitive training, and vascular risk
monitoring versus control to prevent cognitive decline in at-risk
elderly people (FINGER): a randomised controlled trial. Lancet.
2015;385:2255-2263. Abstract
Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects
of the Dietary Approach to stop Hypertension (DASH) diet on
cardiovascular risk factors: a systematic review and meta-analysis. Br J
Nutr. 2015;113:1-15. Abstract
Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.
http://www.medscape.com/viewarticle/869379
---
This email has been checked for viruses by AVG.
http://www.avg.com

http://www.alzheimersanddementia.com/article/S1552-5260(13)01294-6/fulltext
"A molecular mechanism by which acidosis of the brain can lead to
Alzheimer's disease
Conclusions
These findings suggest the involvement of brain acidosis in the
etiopathogenesis of AD, and AEP-I 2 PP2A -PP2A-tau
hyperphosphorylation pathway as a therapeutic target."

Carole missed the context use of the word acidosis refers specifically to
diabetes.

"In acidic conditions such as generated by brain ischemia and hypoxia,
especially in association with hyperglycemia as in diabetes, I 2 PP2A is
cleaved by the lysosomal enzyme asparaginyl endopeptidase (AEP) at N175
into an N-terminal fragment (I 2NTF) and a C-terminal fragment (I 2CTF).
Both I 2NTF and I 2CTF are known to bind to PP2A catalytic subunit and
inhibit its activity."

Hypoxia is a condition where the person doesn't breath deeply enough and
the CO2 levels increasethus acid levels increase as oxygen levels decrease.
Acidosis is the condition where sugars are not processed due to the lack of
insulin, as in ketone acidosis.


Carole,lack of reading comprehension stops her from understanding what she
has read.

Post by ⊙＿⊙
--
A little knowledge is a dangerous thing
"The U.S. government does not study anything holistically. Everything
is studied in isolation from all else."
-- The Open-Source Everything Manifesto: Transparency, Truth, and
Trust (Manifesto Series) by Robert David Steele
http://www.phibetaiota.net/2014/05/robert-steele-at-libtechnyc-the-open-source-everything-manifesto/
http://www.collective-evolution.com/2013/01/07/the-origin-of-education-and-mandatory-schooling/
"From an early age, we are forced into a mandatory school system that
requires and encourages youth to attend for a large portion of their
human life, for six hours a day. Each child is required to learn the
accepted version of reality in order to fit into the specific mold
desired by the elite. Just like television, a large part of school is
simply programming. It’s ironic how the same families behind the
funding are responsible for many inhumane atrocities that took place
throughout history. They are also behind big oil, big pharma, food and
other industries that are becoming more transparent as of late. Kids
who do not fit into the system and do not resonate with it are usually
labelled and medicated. Essentially, the whole point of school is to
shape the reality of the student."

[Duncan]

On Thu, 13 Apr 2017 05:34:51 +0000 (UTC), Bob Officer

Post by Bob Officer

Post by ⊙＿⊙

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?
Response from David B. Reuben, MD
Professor and Archstone Foundation Endowed Chair, Department of
Medicine, University of California, Los Angeles; Chief, Division of
Geriatrics, UCLA Medical Center, Santa Monica, California
Dietary interventions to prevent dementia or cognitive decline are
generally safe, readily available, and can be easier to implement than
interventions such as exercise. But evidence supporting these
interventions varies. Perhaps the best studied is the Mediterranean
diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds,
legumes, fish, and olive oil, and low in red meat, poultry, dairy, and
alcohol. The dietary approach to stop hypertension (DASH) diet is
similar, but is higher in low-fat dairy and lower in fish. The
Mediterranean?DASH intervention for neurodegenerative delay (MIND) diet
incorporates elements of both these diets but places more emphasis on
berries, nuts, and beans.
A meta-analysis of prospective cohort studies showed that people who
adhere to a Mediterranean diet have lower rates of Alzheimer disease and
Parkinson disease.[1] Similarly, studies of community-dwelling older
people who followed the MIND diet showed less decline in global
episodic, semantic, and working memory and in perceptual speed and
perceptual organization at 4.7-year follow-up.[2] In addition, these
study participants were less likely to have developed Alzheimer disease
at 4.5-year follow-up.[3]
Data from some randomized clinical trials support the use of these diets
to prevent cognitive decline and dementia. In the PREDIMED study,
participants 55-80 years of age at high risk for cardiovascular disease
were randomly assigned to one of three diets: a Mediterranean diet with
supplemental extra-virgin olive oil, a Mediterranean diet with
supplemental mixed nuts, or a regular diet that emphasized reduced
dietary fat. There was a reduction in the composite of myocardial
infarction, stroke, and death from cardiovascular causes?the primary
endpoint?with the supplemented Mediterranean diets.[4] A secondary
analysis demonstrated higher scores on the Mini-Mental State Examination
and the clock-drawing test at 6.5 years.[5] In a short-term study,
participants randomized to a DASH diet had better psychomotor speed at
4-month follow-up.[6]
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia.
Diet can also be effective when it is part of a multicomponent
intervention. In the Finnish Geriatric Intervention Study to Prevent
Cognitive Impairment and Disability (FINGER),[7] 1260 participants with
cardiovascular risk factors for dementia and cognitive performance at
the mean or slightly lower than expected for age were randomly assigned
to a multicomponent intervention (diet, exercise, cognitive training,
and vascular risk monitoring) or to health advice (control group).The
dietary component included fruit and vegetables, whole-grain cereal
products, low-fat milk and meat products, low sugar, margarine instead
of butter, and at least two portions of fish per week. The primary
outcome measure was change in performance on a neuropsychological test
battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB
composite score was 25% higher in the intervention group than in the
control group, and executive functioning and processing speed were better in the

intervention

Post by ⊙＿⊙
group. However, memory was no better in the intervention group than in the control group.
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia. Coupled with other
benefits related to hypertension and cardiovascular disease,[4,8]
clinicians should consider recommending these diets for appropriate older people.
Developed in association with the UCLA Alzheimer's and Dementia Care Program.
References
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to
Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline
with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract
Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND
diet associated with reduced incidence of Alzheimer's disease.
Alzheimers Dement. 2015;11:1007-1014. Abstract
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of
cardiovascular disease with a Mediterranean diet. N Engl J Med.
2013;368:1279-1290. Abstract
Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet
improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol
Neurosurg Psychiatry. 2013;84:1318-1325. Abstract
Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary
approaches to stop hypertension diet, exercise, and caloric restriction
on neurocognition in overweight adults with high blood pressure.
Hypertension. 2010;55:1331-1338. Abstract
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain
intervention of diet, exercise, cognitive training, and vascular risk
monitoring versus control to prevent cognitive decline in at-risk
elderly people (FINGER): a randomised controlled trial. Lancet.
2015;385:2255-2263. Abstract
Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects
of the Dietary Approach to stop Hypertension (DASH) diet on
cardiovascular risk factors: a systematic review and meta-analysis. Br J
Nutr. 2015;113:1-15. Abstract
Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.
http://www.medscape.com/viewarticle/869379
---
This email has been checked for viruses by AVG.
http://www.avg.com

http://www.alzheimersanddementia.com/article/S1552-5260(13)01294-6/fulltext
"A molecular mechanism by which acidosis of the brain can lead to
Alzheimer's disease
Conclusions
These findings suggest the involvement of brain acidosis in the
etiopathogenesis of AD, and AEP-I 2 PP2A -PP2A-tau
hyperphosphorylation pathway as a therapeutic target."

Carole missed the context use of the word acidosis refers specifically to
diabetes.

The western diet is acid forming.
Acid is the main cause, if not only cause of disease.

Tell us bob, why do the Japanese who are relatively free of many of
the diseases of modern western society, begin to show same disease
patterns when they switch to standard American diet?

Post by Bob Officer
"In acidic conditions such as generated by brain ischemia and hypoxia,
especially in association with hyperglycemia as in diabetes, I 2 PP2A is
cleaved by the lysosomal enzyme asparaginyl endopeptidase (AEP) at N175
into an N-terminal fragment (I 2NTF) and a C-terminal fragment (I 2CTF).
Both I 2NTF and I 2CTF are known to bind to PP2A catalytic subunit and
inhibit its activity."
Hypoxia is a condition where the person doesn't breath deeply enough and
the CO2 levels increasethus acid levels increase as oxygen levels decrease.
Acidosis is the condition where sugars are not processed due to the lack of
insulin, as in ketone acidosis.

And your lack of rational thinking means you read everything
mainstream puts out and then accept it as bible.

Sorry about bob folks, he is a stickler for mainstream protocol.
ie a dumbarse.

Post by Bob Officer
Carole,lack of reading comprehension stops her from understanding what she
has read.

--
Duncan

"Consensus is not a scientific term. It is a political term." (Ed. The
Climate Skeptics (TCS) Blog)

"There are known knowns. These are things we know that we know. There
are known unknowns. That is to say, there are things that we know we
don't know. But there are also unknown unknowns. There are things we
don't know we don't know." -- Donald Rumsfeld

"If they can get you asking the wrong questions, they don't have to
worry about answers." - Thomas Pynchon, Gravity's Rainbow

Post by Bob Officer
[BOB] "Beliefs are not opinions."
I think you will find that "belief" is a synonym for "opinion".
So WTF are you trying to say idiot?

[BOB] "I stand by what I said in context. A belief is
something held true with or without supporting
evidence or in the face of contradictory evidence.

An opinion is based on what one thinks and not what
one believes. Ones religion is what one believes.
Religion requires no thinking and in many cases
Religion forbids thinking.

While you might believe their are interchangeable
synonyms, I think if you asked an expert in the
English Language they might agree with me. The
words have different meanings and uses."
--------

">I didn't know there was a requirement to generate topics. Where did

Post by Bob Officer
you get that idiotic idea from. " -- Bob Officer

DK: Bob Officer is a member of the group I
DK; accurately describe as...
PSEUDO-SKEPTIC-FANATICS (PSF)
http://www.psicounsel.com/bobofficer.html

[The Newest Other Guy]

Post by Duncan
The western diet is acid forming.
Acid is the main cause, if not only cause of disease.

Once AND STILL totally bullshit.

[Bob Officer]

Post by Duncan
On Thu, 13 Apr 2017 05:34:51 +0000 (UTC), Bob Officer

Post by Bob Officer

Post by ⊙＿⊙

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?
Response from David B. Reuben, MD
Professor and Archstone Foundation Endowed Chair, Department of
Medicine, University of California, Los Angeles; Chief, Division of
Geriatrics, UCLA Medical Center, Santa Monica, California
Dietary interventions to prevent dementia or cognitive decline are
generally safe, readily available, and can be easier to implement than
interventions such as exercise. But evidence supporting these
interventions varies. Perhaps the best studied is the Mediterranean
diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds,
legumes, fish, and olive oil, and low in red meat, poultry, dairy, and
alcohol. The dietary approach to stop hypertension (DASH) diet is
similar, but is higher in low-fat dairy and lower in fish. The
Mediterranean?DASH intervention for neurodegenerative delay (MIND) diet
incorporates elements of both these diets but places more emphasis on
berries, nuts, and beans.
A meta-analysis of prospective cohort studies showed that people who
adhere to a Mediterranean diet have lower rates of Alzheimer disease and
Parkinson disease.[1] Similarly, studies of community-dwelling older
people who followed the MIND diet showed less decline in global
episodic, semantic, and working memory and in perceptual speed and
perceptual organization at 4.7-year follow-up.[2] In addition, these
study participants were less likely to have developed Alzheimer disease
at 4.5-year follow-up.[3]
Data from some randomized clinical trials support the use of these diets
to prevent cognitive decline and dementia. In the PREDIMED study,
participants 55-80 years of age at high risk for cardiovascular disease
were randomly assigned to one of three diets: a Mediterranean diet with
supplemental extra-virgin olive oil, a Mediterranean diet with
supplemental mixed nuts, or a regular diet that emphasized reduced
dietary fat. There was a reduction in the composite of myocardial
infarction, stroke, and death from cardiovascular causes?the primary
endpoint?with the supplemented Mediterranean diets.[4] A secondary
analysis demonstrated higher scores on the Mini-Mental State Examination
and the clock-drawing test at 6.5 years.[5] In a short-term study,
participants randomized to a DASH diet had better psychomotor speed at
4-month follow-up.[6]
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia.
Diet can also be effective when it is part of a multicomponent
intervention. In the Finnish Geriatric Intervention Study to Prevent
Cognitive Impairment and Disability (FINGER),[7] 1260 participants with
cardiovascular risk factors for dementia and cognitive performance at
the mean or slightly lower than expected for age were randomly assigned
to a multicomponent intervention (diet, exercise, cognitive training,
and vascular risk monitoring) or to health advice (control group).The
dietary component included fruit and vegetables, whole-grain cereal
products, low-fat milk and meat products, low sugar, margarine instead
of butter, and at least two portions of fish per week. The primary
outcome measure was change in performance on a neuropsychological test
battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB
composite score was 25% higher in the intervention group than in the
control group, and executive functioning and processing speed were better in the

intervention

Post by ⊙＿⊙
group. However, memory was no better in the intervention group than in
the control group.
This body of evidence is suggestive of, but not conclusive for, the
benefit of a healthy diet on cognition and dementia. Coupled with other
benefits related to hypertension and cardiovascular disease,[4,8]
clinicians should consider recommending these diets for appropriate older people.
Developed in association with the UCLA Alzheimer's and Dementia Care Program.
References
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to
Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline
with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract
Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND
diet associated with reduced incidence of Alzheimer's disease.
Alzheimers Dement. 2015;11:1007-1014. Abstract
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of
cardiovascular disease with a Mediterranean diet. N Engl J Med.
2013;368:1279-1290. Abstract
Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet
improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol
Neurosurg Psychiatry. 2013;84:1318-1325. Abstract
Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary
approaches to stop hypertension diet, exercise, and caloric restriction
on neurocognition in overweight adults with high blood pressure.
Hypertension. 2010;55:1331-1338. Abstract
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain
intervention of diet, exercise, cognitive training, and vascular risk
monitoring versus control to prevent cognitive decline in at-risk
elderly people (FINGER): a randomised controlled trial. Lancet.
2015;385:2255-2263. Abstract
Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects
of the Dietary Approach to stop Hypertension (DASH) diet on
cardiovascular risk factors: a systematic review and meta-analysis. Br J
Nutr. 2015;113:1-15. Abstract
Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.
http://www.medscape.com/viewarticle/869379
---
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http://www.alzheimersanddementia.com/article/S1552-5260(13)01294-6/fulltext
"A molecular mechanism by which acidosis of the brain can lead to
Alzheimer's disease
Conclusions
These findings suggest the involvement of brain acidosis in the
etiopathogenesis of AD, and AEP-I 2 PP2A -PP2A-tau
hyperphosphorylation pathway as a therapeutic target."

Carole missed the context use of the word acidosis refers specifically to
diabetes.

The western diet is acid forming.

Not according to this article, Carole.

Actually not one bit of science supports that claim. ZERO evidence exists
which even give credence to your worthless and nonsensical claim.

Post by Duncan
Acid is the main cause, if not only cause of disease.

And evidence is?

Post by Duncan
Tell us bob, why do the Japanese who are relatively free of many of
the diseases of modern western society, begin to show same disease
patterns when they switch to standard American diet?

Post by Bob Officer
"In acidic conditions such as generated by brain ischemia and hypoxia,
especially in association with hyperglycemia as in diabetes, I 2 PP2A is
cleaved by the lysosomal enzyme asparaginyl endopeptidase (AEP) at N175
into an N-terminal fragment (I 2NTF) and a C-terminal fragment (I 2CTF).
Both I 2NTF and I 2CTF are known to bind to PP2A catalytic subunit and
inhibit its activity."
Hypoxia is a condition where the person doesn't breath deeply enough and
the CO2 levels increasethus acid levels increase as oxygen levels decrease.
Acidosis is the condition where sugars are not processed due to the lack of
insulin, as in ketone acidosis.

And your lack of rational thinking means you read everything
mainstream puts out and then accept it as bible.

I pointed out the article you cited doesn't support your claim, Carole. You
didn't understand it at all.

Post by Duncan
Sorry about bob folks, he is a stickler for mainstream protocol.
ie a dumbarse.

Psychological projection again, Carole. The fact you posted an article in
the belief it supported your nonsense. It didn't, and still doesn't. You
are fixated on certain terms and still do not know how to read.

Post by Duncan

Post by Bob Officer
Carole's lack of reading comprehension stops her from understanding what she
has read.

[A little knowledge]

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?

No doubt there are alternative cures for alzheimers disease.
Mainstream says its incurable but that's due to the fact that
mainstream is dominated by the pharmaceutical industry that won't
allow any cures that can't be patented.

The standard excuse is "there is no evidence to support any
alternative treatments" which in fact means nothing since no studies
will be recognised or supported by mainstream to support any product
that challenges big pharma profits.


--
A little knowledge is a dangerous thing



Is Big Pharma Addicted To Fraud?
http://www.forbes.com/sites/erikakelton/2013/07/29/is-big-pharma-addicted-to-fraud/


Patents Over Patients
http://www.nytimes.com/2007/04/01/opinion/01moss.html
"We could make faster progress against cancer by changing the way
drugs are developed. In the current system, if a promising compound
can’t be patented, it is highly unlikely ever to make it to market"

Post by ⊙＿⊙
Response from David B. Reuben, MD
Professor and Archstone Foundation Endowed Chair, Department of Medicine, University of California, Los Angeles; Chief, Division of Geriatrics, UCLA Medical Center, Santa Monica, California
Dietary interventions to prevent dementia or cognitive decline are generally safe, readily available, and can be easier to implement than interventions such as exercise. But evidence supporting these interventions varies. Perhaps the best studied is the Mediterranean diet, which is high in grains, vegetables, fruit, potatoes, nuts, seeds, legumes, fish, and olive oil, and low in red meat, poultry, dairy, and alcohol. The dietary approach to stop hypertension (DASH) diet is similar, but is higher in low-fat dairy and lower in fish. The Mediterranean–DASH intervention for neurodegenerative delay (MIND) diet incorporates elements of both these diets but places more emphasis on berries, nuts, and beans.
A meta-analysis of prospective cohort studies showed that people who adhere to a Mediterranean diet have lower rates of Alzheimer disease and Parkinson disease.[1] Similarly, studies of community-dwelling older people who followed the MIND diet showed less decline in global episodic, semantic, and working memory and in perceptual speed and perceptual organization at 4.7-year follow-up.[2] In addition, these study participants were less likely to have developed Alzheimer disease at 4.5-year follow-up.[3]
Data from some randomized clinical trials support the use of these diets to prevent cognitive decline and dementia. In the PREDIMED study, participants 55-80 years of age at high risk for cardiovascular disease were randomly assigned to one of three diets: a Mediterranean diet with supplemental extra-virgin olive oil, a Mediterranean diet with supplemental mixed nuts, or a regular diet that emphasized reduced dietary fat. There was a reduction in the composite of myocardial infarction, stroke, and death from cardiovascular causes—the primary endpoint—with the supplemented Mediterranean diets.[4] A secondary analysis demonstrated higher scores on the Mini-Mental State Examination and the clock-drawing test at 6.5 years.[5] In a short-term study, participants randomized to a DASH diet had better psychomotor speed at 4-month follow-up.[6]
This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia.
Diet can also be effective when it is part of a multicomponent intervention. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER),[7] 1260 participants with cardiovascular risk factors for dementia and cognitive performance at the mean or slightly lower than expected for age were randomly assigned to a multicomponent intervention (diet, exercise, cognitive training, and vascular risk monitoring) or to health advice (control group).The dietary component included fruit and vegetables, whole-grain cereal products, low-fat milk and meat products, low sugar, margarine instead of butter, and at least two portions of fish per week. The primary outcome measure was change in performance on a neuropsychological test battery (NTB) of 14 tests. During the 24-month follow-up period, the NTB composite score was 25% higher in the intervention group than in the control group, and executive functioning and processing speed were better in the

intervention

Post by ⊙＿⊙
group. However, memory was no better in the intervention group than in the control group.
This body of evidence is suggestive of, but not conclusive for, the benefit of a healthy diet on cognition and dementia. Coupled with other benefits related to hypertension and cardiovascular disease,[4,8] clinicians should consider recommending these diets for appropriate older people.
Developed in association with the UCLA Alzheimer's and Dementia Care Program.
References
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11:1015-1022. Abstract
Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015;11:1007-1014. Abstract
Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-1290. Abstract
Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84:1318-1325. Abstract
Smith PJ, Blumenthal JA, Babyak MA, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 2010;55:1331-1338. Abstract
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255-2263. Abstract
Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the Dietary Approach to stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015;113:1-15. Abstract
Cite this article: Can a Good Diet Prevent Dementia?. Medscape. Sep 30, 2016.
http://www.medscape.com/viewarticle/869379
---
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[The Newest Other Guy]

On Thu, 13 Apr 2017 17:18:40 +1000, A little knowledge

Post by A little knowledge

Post by ⊙＿⊙
Can a Good Diet Prevent Dementia?
David B. Reuben, MD|September 30, 2016
Question
Can a good diet prevent dementia?

No doubt there are alternative cures for alzheimers disease.

NAME one, JUST one!!